Effect of naloxone on the pulsatile secretion of luteinizing hormone in gonadectomized male and female ferrets before and after oestradiol replacement.

Abstract Intravenous infusions of the opioid receptor antagonist, naloxone, caused a significant rise in luteinizing hormone (LH) pulse frequency in male and female ferrets which had been gonadectomized 10 days earlier while in breeding condition; mean LH concentrations and LH pulse amplitudes were not affected. By contrast, naloxone failed to stimulate LH… CONTINUE READING