Effect of naloxone on the adrenal cortex in primary aldosteronism.

  title={Effect of naloxone on the adrenal cortex in primary aldosteronism.},
  author={Francesco Fallo and Marco Boscaro and Nicoletta Sonino and Franco Mantero},
  journal={American journal of hypertension},
  volume={1 3 Pt 1},
Endogenous opioids have been suggested to play a pathogenetic role in idiopathic hyperaldosteronism (IHA). To investigate this issue, the opiate antagonist naloxone was administered to 8 normals and 14 patients with primary aldosteronism, 6 with an aldosterone-producing adenoma (APA) and 8 with IHA. In normals, APA, and IHA, naloxone caused a significant increase in plasma cortisol and no change in ACTH, renin activity (PRA), and aldosterone levels. All subjects were retested after… CONTINUE READING