Effect of naloxone on plasma insulin, insulin-like growth factor I, and its binding protein 1 in patients with polycystic ovarian disease.

@article{Laatikainen1990EffectON,
  title={Effect of naloxone on plasma insulin, insulin-like growth factor I, and its binding protein 1 in patients with polycystic ovarian disease.},
  author={T. J. Laatikainen and Leena Anttila and Anne Maria Suikkari and K Ruutiainen and Risto U Erkkola and Markku Sepp{\"a}l{\"a}},
  journal={Fertility and sterility},
  year={1990},
  volume={54 3},
  pages={434-7}
}
Insulin and insulin-like growth factors (IGFs) stimulate ovarian steroidogenesis, and hyperinsulinemia is often accompanied by hyperandrogenemia in women with polycystic ovarian disease (PCOD). Because opioid peptides are involved in the regulation of insulin secretion, we studied the effect of naloxone-induced opiate receptor blockade on the circulating levels of insulin, IGF-I, and IGF binding protein 1 (IGFBP-1) in 13 nonobese and 7 obese PCOD patients and in 6 healthy subjects. In obese… CONTINUE READING

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