Effect of naloxone on perceived exertion and exercise capacity during maximal cycle ergometry.

  title={Effect of naloxone on perceived exertion and exercise capacity during maximal cycle ergometry.},
  author={Anthony L Sgherza and Kenneth Axen and Randi Fain and Robert S Hoffman and Christopher C. Dunbar and François Haas},
  journal={Journal of applied physiology},
  volume={93 6},
We assessed the effects of naloxone, an opioid antagonist, on exercise capacity in 13 men and 5 women (mean age = 30.1 yr, range = 21-35 yr) during a 25 W/min incremental cycle ergometer test to exhaustion on different days during familiarization trial and then after 30 mg (iv bolus) of naloxone or placebo (Pl) in a double-blind, crossover design. Minute ventilation (Ve), O(2) consumption (Vo(2)), CO(2) production, and heart rate (HR) were monitored. Perceived exertion rating (0-10 scale) and… CONTINUE READING
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