Effect of naloxone on intake of cornstarch, sucrose, and polycose diets in restricted and nonrestricted rats.

@article{Weldon1996EffectON,
  title={Effect of naloxone on intake of cornstarch, sucrose, and polycose diets in restricted and nonrestricted rats.},
  author={Derik T. Weldon and Eugene O'Hare and James P. Cleary and Charles J. Billington and Allen Stuart Levine},
  journal={The American journal of physiology},
  year={1996},
  volume={270 6 Pt 2},
  pages={R1183-8}
}
We studied the effect of the opioid receptor antagonist naloxone on intake of three isocaloric diets containing cornstarch, sucrose, or Polycose as the predominant carbohydrate in ad libitum-fed and food-restricted rats. A large body of evidence suggests that opioids affect palatability (reward)-rater than hunger (energy deficit)-driven food intake. We expected food intake to be driven by both energy needs and palatability in ad libitum-fed rats, whereas in food-restricted rats we expected… CONTINUE READING

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