Effect of myricetin and other flavonoids on the liver plasma membrane Ca2+ pump. Kinetics and structure-function relationships.

@article{Thiyagarajah1991EffectOM,
  title={Effect of myricetin and other flavonoids on the liver plasma membrane Ca2+ pump. Kinetics and structure-function relationships.},
  author={P Thiyagarajah and S C Kuttan and Sung Cil Lim and Tian Seng Teo and Nagaratnam P. Das},
  journal={Biochemical pharmacology},
  year={1991},
  volume={41 5},
  pages={
          669-75
        }
}
Thirty-three different flavonoids were screened for their ability to influence ATP-dependent Ca2+ uptake by rat liver plasma membrane vesicles. Nine of the flavonoids, at a concentration of 100 microM inhibited Ca2+ uptake by more than 20%. The remaining 24 flavonoids exhibited little or no effect. The relative order of potency of the more biologically active flavonoids was myricetin greater than butein greater than phloretin = luteolin greater than eriodictyol = silybin. Myricitrin and… CONTINUE READING
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