Effect of myocardial perfusion and metabolic interventions on cardiac kinetics of phenylpentadecanoic acid (IPPA) I 123

@article{Reske1986EffectOM,
  title={Effect of myocardial perfusion and metabolic interventions on cardiac kinetics of phenylpentadecanoic acid (IPPA) I 123},
  author={Sven N. Reske and Sylvia Sch{\"o}n and Wilhelm Schmitt and Hans Juergen Machulla and Reinhold Knopp and Cuno Winkler},
  journal={European Journal of Nuclear Medicine},
  year={1986},
  volume={12},
  pages={S27-S31}
}
The effect of regional myocardial perfusion and flow-independent adrenergic stimulation, as well as lactatemediated inhibition of cardiac lipolysis, on cardiac IPPA uptake and metabolism was examined in canine hearts (flow studies) and in the isolated perfused Langendorff rat heart (metabolic interventions). In both normal and ischaemic myocardium, local perfusion is a major determinant of cardiac IPPA uptake. In pacing-induced hyperaemia, the strict flow-dependence of cardiac IPPA uptake is… CONTINUE READING

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