Corpus ID: 45948591

Effect of mycelial extract of Clavicorona pyxidata on the production of amyloid beta-peptide and the inhibition of endogenous beta-secretase activity in vitro.

@article{Lee2006EffectOM,
  title={Effect of mycelial extract of Clavicorona pyxidata on the production of amyloid beta-peptide and the inhibition of endogenous beta-secretase activity in vitro.},
  author={Tae-Hee Lee and Young-il Park and Yeong-Hwan Han},
  journal={Journal of microbiology},
  year={2006},
  volume={44 6},
  pages={
          665-70
        }
}
Amyloid beta-peptide (Abeta), which is a product of the proteolytic effect of beta-secretase (BACE) on an amyloid precursor protein, is closely associated with Alzheimer's disease (AD) pathogenesis. There is sufficient evidence to suggest that a BACE inhibitor may reduce Abeta levels, thus decreasing the risk of AD. In a previous study, an extract of Clavicorona pyxidata DGUM 29005 mycelia was found to inhibit the production of a soluble beta-amyloid precursor protein (sbetaAPP), Abeta, and… Expand

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