Effect of mutator P. aeruginosa on antibiotic resistance acquisition and respiratory function in cystic fibrosis.

@article{Ferroni2009EffectOM,
  title={Effect of mutator P. aeruginosa on antibiotic resistance acquisition and respiratory function in cystic fibrosis.},
  author={Agn{\'e}s Ferroni and Didier Guillemot and Kaoutar Moumile and Claire Bern{\`e}de and Muriel le Bourgeois and Serge Waernessyckle and Philippe Descamps and Isabelle Sermet-Gaudelus and G{\'e}rard Lenoir and Patrick Berche and François Taddei},
  journal={Pediatric pulmonology},
  year={2009},
  volume={44 8},
  pages={820-5}
}
BACKGROUND Cystic fibrosis patients suffer from recurrent bacterial infections that result in progressive deterioration of their respiratory function. Despite intensive antibiotic treatment, Pseudomonas aeruginosa is the main cause of such infections, with clones progressively developing multiple antibiotic resistance. We determined the relationship between the presence of P. aeruginosa mutator strains and cystic fibrosis clinical characteristics. METHODS We analyzed 136 strains of P… CONTINUE READING

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Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients.

Proceedings of the National Academy of Sciences of the United States of America • 2006
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