Effect of mutations in vesicle-associated membrane protein (VAMP) on the assembly of multimeric protein complexes.

@article{Hao1997EffectOM,
  title={Effect of mutations in vesicle-associated membrane protein (VAMP) on the assembly of multimeric protein complexes.},
  author={Joe C. Hao and Norman Salem and Xing Peng and Regis B. Kelly and M. K. Bennett},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 5},
  pages={1596-603}
}
The assembly of multimeric protein complexes that include vesicle-associated membrane protein 2 (VAMP-2) and the plasma membrane proteins syntaxin 1A and synaptosome-associated protein of 25 kDa (SNAP-25) are thought to reflect the biochemical correlates of synaptic vesicle targeting, priming, or fusion. Using a variety of protein-protein interaction assays and a series of deletion and point mutations, we have investigated the domains of VAMP-2 required for the formation of binary complexes… CONTINUE READING