Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRL1 and AFX.

@article{Woods2002EffectOM,
  title={Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRL1 and AFX.},
  author={Yvonne L. Woods and Graham Rena},
  journal={Biochemical Society transactions},
  year={2002},
  volume={30 4},
  pages={391-7}
}
The insulin-stimulated phosphoinositide 3-kinase (PI 3-kinase)/3-phosphoinositide-dependent kinase-1 (PDK1)/protein kinase B (PKB) kinase cascade is believed to play a critical role in metabolic control and cell survival, largely mediated through PKB phosphorylation of many proteins. Recent findings demonstrate that the transcription factors FKHR (forkhead in rhabdomyosarcoma), AFX (ALL1 fused gene from chromosome X) and FKHRL1 (FKHR-like 1; termed FKHR isoforms) are phosphorylated by PKB in… CONTINUE READING
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