Effect of moxifloxacin on production of proinflammatory cytokines from human peripheral blood mononuclear cells.

@article{Choi2003EffectOM,
  title={Effect of moxifloxacin on production of proinflammatory cytokines from human peripheral blood mononuclear cells.},
  author={Jung-Hyun Choi and Min-Jin Song and Seung-Han Kim and Su-Mi Choi and Dong-gun Lee and Ji Young Yoo and Weon Seung Shin},
  journal={Antimicrobial agents and chemotherapy},
  year={2003},
  volume={47 12},
  pages={
          3704-7
        }
}
The effects of moxifloxacin, a new methoxyfluoroquinolone, on the production of proinflammatory cytokines from human peripheral blood mononuclear cells (PBMCs) were evaluated. Moxifloxacin inhibited the production of tumor necrosis factor alpha (TNF-alpha) and/or interleukin-6 (IL-6) by PBMCs stimulated with lipopolysaccharide (LPS), lipoteichoic acid (LTA), and heat-killed bacteria in a concentration-dependent manner without cytotoxic effects. The addition of moxifloxacin reduced the… CONTINUE READING

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