Effect of morphine on proopiomelanocortin gene expression and peptide levels in the hypothalamus.

@article{Wardlaw1996EffectOM,
  title={Effect of morphine on proopiomelanocortin gene expression and peptide levels in the hypothalamus.},
  author={Sharon L Wardlaw and Jong-woo Kim and Sławomir Sobieszczyk},
  journal={Brain research. Molecular brain research},
  year={1996},
  volume={41 1-2},
  pages={140-7}
}
Opiates have been reported to suppress POMC in the medial basal hypothalamus (MBH) but studies have been complicated by the fact that acutely, in the rat, opiates stimulate corticosterone and inhibit gonadal steroid release, which could both affect POMC in brain. We have therefore examined POMC gene expression and peptide levels in the MBH of castrated rats after 10 days of treatment with subcutaneous morphine or placebo pellets and after pellet removal. POMC mRNA was measured by solution… CONTINUE READING

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