Effect of morphine and naloxone on a defensive response of the crab Chasmagnathus granulatus

@article{Lozada1988EffectOM,
  title={Effect of morphine and naloxone on a defensive response of the crab Chasmagnathus granulatus
},
  author={Mariana Lozada and Arturo Romano and H{\'e}ctor Maldonado},
  journal={Pharmacology Biochemistry and Behavior},
  year={1988},
  volume={30},
  pages={635-640}
}
Male crabs (Chasmagnathus granulatus) exhibited a defensive response (DR) to an electric shock (8 V, 50 Hz, 1 sec). The DR so elicited was used as a model for studying the antinociceptive effect of morphine. Injections of morphine-HCl (MP) (25, 50, 100 and 150 micrograms/g) were administered and the DR was examined at 2, 7.5, 15, 30, 45 and 75 min post-injection. (a) MP produced a dose-dependent reduction of the crab's sensitivity to the nociceptive stimulus. (b) A 100 micrograms/g dose of MP… Expand
Opioid action on response level to a danger stimulus in the crab (Chasmagnathus granulatus).
When a passing shadow is presented to the crab (Chasmagnathus granulatus), an escape response is elicited that habituates after repeated stimulation. Results of previous papers suggest that thisExpand
Effect of naloxone pretreatment on habituation in the crab Chasmagnathus granulatus.
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The hypothesis that crab's habituation involves the action of an endogenous opioid mechanism is put forward to account for the naloxone pretreatment effect. Expand
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These results and those previously obtained as the action of GABA on the LMD of this crab are discussed in connection with results reporting a similar effect of these drugs on another agonistic item of behavior in the crab Chasmagnatus granulatus. Expand
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The effect of the opiate morphine and opioid neuropeptides Endomorphin 1 and 2 on the thermal avoidance (Tav) behavior of Caenorhabditis elegans is explored and Naloxone and CTOP were tested in combination with the drugs. Expand
Habituation in the crabChasmagnathus granulatus: effect of morphine and naloxone
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Results concerning stimulus generalization and dishabituation strongly suggest that neither motor fatigue nor sensory adaptation can account for the response waning, and the potential value of the response habituation as a model for studying both habituation dynamics and the mechanisms that subserve it is discussed. Expand
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Issues concerning dependence of the analgesia on danger stimulus iteration and on stimulus controllability, as well as the opioid nature ofThe analgesia, are discussed. Expand
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The hypothesis that morphine effects may be explained by transient disruption between the stimulus and its danger meaning is supported, ruling out alternative explanations such as response inhibition or amnesia due to either storage or retrieval failure. Expand
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