Effect of monocytes/macrophages on the early osteogenic differentiation of hBMSCs.

@article{Pirraco2013EffectOM,
  title={Effect of monocytes/macrophages on the early osteogenic differentiation of hBMSCs.},
  author={Rog{\'e}rio Pedro Pirraco and Rui L. Reis and Alexandra Pinto Marques},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2013},
  volume={7 5},
  pages={392-400}
}
Heterotypic cell interactions are essential for the homeostasis of bone tissue, in particular the widely studied interaction between osteoblasts and osteoclasts. Closely related with osteoclasts are monocytes/macrophages. These have been shown to produce osteogenic factors, e.g. BMP-2, which plays a key role in bone metabolism. However, the mechanisms through which monocytes/macrophages interact with osteoblasts are still elusive. The aim of this work was to assess the influence of human… CONTINUE READING