Effect of monensin on receptor recycling during continuous endocytosis of asialoorosomucoid.

@article{Kaiser1988EffectOM,
  title={Effect of monensin on receptor recycling during continuous endocytosis of asialoorosomucoid.},
  author={Johannes Kaiser and Richard J. Stockert and Allan W. Wolkoff},
  journal={Experimental cell research},
  year={1988},
  volume={174 2},
  pages={472-80}
}
The binding of asialoglycoproteins to their liver cell receptor results in internalization of the ligand-receptor complex. These complexes rapidly appear in intracellular compartments termed endosomes whose acidification results in ligand-receptor dissociation. Ligand and receptor subsequently segregate: ligand is transported to lysosomes and is degraded while receptor recycles to the cell surface. The proton ionophore monensin prevents acidification of endosomes and reversibly inhibits this… CONTINUE READING

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