Effect of molecular weight on the dermatopharmacokinetics and systemic disposition of drugs after intracutaneous injection.

Abstract

The aim of this study was to investigate the effect of molecular weight on the topical migration and systemic absorption of drugs, sodium salicylate (SA), calcein sodium (CAL) and FITC-dextrans (FD-4, FD-10, FD-20 and FD-40), after intracutaneous (i.c.) injection. The apparent diffusion coefficients in the skin (D(s)) of SA, CAL and FD-4 after i.c… (More)
DOI: 10.1016/j.ejps.2008.04.003

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