Effect of molecular adsorbent recirculating system in hepatitis C virus‐related intractable pruritus

@article{Doria2003EffectOM,
  title={Effect of molecular adsorbent recirculating system in hepatitis C virus‐related intractable pruritus},
  author={Cataldo Doria and Lucio Mandala' and Jan D. Smith and Claudio H. Vitale and Augusto Lauro and Salvatore Gruttadauria and Ignazio Marino and Carlo Scotti Foglieni and Mario Magnone and Victor L. Scott},
  journal={Liver Transplantation},
  year={2003},
  volume={9}
}
Intractable pruritus is more common in cholestatic liver diseases and may be the presenting symptom and/or major complaint of hepatitis C and/or hepatitic C virus—related cirrhosis. From September 2000 to May 2002, three patients affected by intractable pruritus secondary to hepatitis C cirrhosis that failed medical treatment were treated with a molecular adsorbent recirculating system (MARS). MARS is an artificial liver support system that aims to clear the blood of metabolic waste products… 
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TLDR
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TLDR
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Mediators of pruritus during cholestasis
TLDR
It is hypothesized that during cholestasis expression of autotaxin is induced, which gives rise to increased local formation of LPA near unmyelinated nerve endings of itch fibres leading to the perception of pruritus.
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