Effect of moisture on polyvinylpyrrolidone in accelerated stability testing.

  title={Effect of moisture on polyvinylpyrrolidone in accelerated stability testing.},
  author={Shaun Fitzpatrick and James F McCabe and Catherine R Petts and Steven W Booth},
  journal={International journal of pharmaceutics},
  volume={246 1-2},
Accelerated stability studies are a common approach for predicting the long-term stability of pharmaceutical formulations. However, in this study, a slowing of dissolution was observed for a formulation following storage at elevated temperature and humidity. The moisture sorption isotherm for the binder, polyvinylpyrrolidone (PVP), shows absorption of a significant quantity of water on exposure to elevated humidity. Modulated temperature differential scanning calorimetry (mDSC) has been used to… CONTINUE READING

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