Effect of modification of the length and flexibility of the acyl carrier protein-thioesterase interdomain linker on functionality of the animal fatty acid synthase.

@article{Joshi2005EffectOM,
  title={Effect of modification of the length and flexibility of the acyl carrier protein-thioesterase interdomain linker on functionality of the animal fatty acid synthase.},
  author={Anil Kumar Joshi and Andrzej Witkowski and Harvey Alan Berman and Lei Zhang and Stuart Smith},
  journal={Biochemistry},
  year={2005},
  volume={44 10},
  pages={4100-7}
}
A natural linker of approximately 20 residues connects the acyl carrier protein with the carboxy-terminal thioesterase domain of the animal fatty acid synthase. This study examines the effects of changes in the length and amino acid composition of this linker on catalytic activity, product composition, and segmental motion of the thioesterase domain… CONTINUE READING