Effect of model selection on prediction of periodic behavior in gene regulatory networks.

@article{Gedeon2012EffectOM,
  title={Effect of model selection on prediction of periodic behavior in gene regulatory networks.},
  author={Tom{\'a}s Gedeon and Graham Cummins and Jeffrey J. Heys},
  journal={Bulletin of mathematical biology},
  year={2012},
  volume={74 8},
  pages={1706-26}
}
One of the current challenges for cell biology is understanding of the system level cellular behavior from the knowledge of a network of the individual subcellular agents. We address a question of how the model selection affects the predicted dynamic behavior of a gene network. In particular, for a fixed network structure, we compare protein-only models with models in which each transcriptional activation is represented both by mRNA and protein concentrations. We compare linear behavior near… CONTINUE READING

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