Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium(I) in cultured mouse fibroblasts.

@article{Chiu1990EffectOM,
  title={Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium(I) in cultured mouse fibroblasts.},
  author={Mary L. Chiu and James F. Kronauge and David R. Piwnica-Worms},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1990},
  volume={31 10},
  pages={1646-53}
}
Hexakis(2-methoxyisobutylisonitrile) technetium(I) (Tc-MIBI) is representative of a class of 99mTc-based lipophilic cationic myocardial perfusion imaging agents. To test the hypothesis that the mechanism of cellular uptake may involve distribution across biologic membranes in response to membrane potential, Tc-MIBI net uptake and retention were determined… CONTINUE READING