Effect of minocycline on pentylenetetrazol-induced chemical kindled seizures in mice

@article{Ahmadirad2013EffectOM,
  title={Effect of minocycline on pentylenetetrazol-induced chemical kindled seizures in mice},
  author={Nooshin Ahmadirad and Amir Shojaei and Mohammad Javan and Mohammad Hossein Pourgholami and Javad Mirnajafi-zadeh},
  journal={Neurological Sciences},
  year={2013},
  volume={35},
  pages={571-576}
}
Inflammation is one of the mechanisms involved in seizure induction. In this study, the effect of minocycline, an anti-inflammatory drug, was investigated on kindling acquisition. Chemical kindling was induced by injection of a subthreshold dose of pentylenetetrazol (PTZ; 37.5 mg/kg) in mice on every other day. Two groups of animals received minocycline (25 mg/kg) at 1 h before or 1 h after PTZ injection. Following the last PTZ injection, the changes in gene expression of TNF-α receptor, γ2… CONTINUE READING
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