Effect of microcystin-LR and cyanobacterial extract from Polish reservoir of drinking water on cell cycle progression, mitotic spindle, and apoptosis in CHO-K1 cells.

@article{Lankoff2003EffectOM,
  title={Effect of microcystin-LR and cyanobacterial extract from Polish reservoir of drinking water on cell cycle progression, mitotic spindle, and apoptosis in CHO-K1 cells.},
  author={Anna Lankoff and Anna Banasik and Guenter Obe and Marta Deperas and Konrad Kuzminski and Malgorzata Tarczynska and Tomasz Jurczak and Andrzej Wojcik},
  journal={Toxicology and applied pharmacology},
  year={2003},
  volume={189 3},
  pages={204-13}
}
Microcystin-LR is a cyanobacterial toxin possessing a potent tumor-promoting activity mediated through inhibition of protein phosphatases PP1 and PP2A. Because these enzymes are involved in fundamental cell processes, we decided to examine the influence of microcystin-LR on cell cycle progression, onset of anaphase, segregation of chromosomes by the mitotic spindle, and apoptosis in Chinese hamster ovary (CHO-K1) cells. Cells were incubated with 25, 50, and 100 microM of pure microcystin-LR and… CONTINUE READING
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