Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: a review.

@article{Song2012EffectOM,
  title={Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: a review.},
  author={Erwei Song and Shen-jiang Hu},
  journal={Journal of biochemical and molecular toxicology},
  year={2012},
  volume={26 2},
  pages={79-86}
}
The tumor suppressor gene p53 was shown to directly regulate the expression of microRNA-34a (miR-34a). miR-34a regulates a plethora of target proteins, which are involved in cell cycle, apoptosis, differentiation, and cellular development.miR-34a resides in the region of chromosome 1p36.23, which is commonly deleted in many tumor types, while it results in the loss expression of miR-34a. The promoters of the miR-34a gene subject to inactivation by CpG methylation also induce the loss expression… CONTINUE READING