• Corpus ID: 3997702

Effect of miR-203 expression on myocardial fibrosis.

@article{He2017EffectOM,
  title={Effect of miR-203 expression on myocardial fibrosis.},
  author={Q He and C-M Wang and J Qin and Y-j Zhang and Dong Xia and X L Chen and S-Z Guo and X.D Zhao and Qianqian Guo and C.-Z. Lu},
  journal={European review for medical and pharmacological sciences},
  year={2017},
  volume={21 4},
  pages={
          837-842
        }
}
  • Q. He, C-M Wang, C. Lu
  • Published 1 February 2017
  • Biology
  • European review for medical and pharmacological sciences
OBJECTIVE Cardiovascular disease is one of the diseases threatening human health. Myocardial fibrosis is a major cause of cardiovascular diseases. Studies have shown that over expression of miR-203 can inhibit the fibrosis. Therefore, in this study, the effect of differential expression of miR-203 on fibrosis of cultured mouse cardiomyocytes was investigated. MATERIALS AND METHODS Activators and inhibitors of miR-203 were designed according to the sequence of miR-203, synthesized, and… 

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References

SHOWING 1-10 OF 23 REFERENCES
MicroRNA‐503 promotes angiotensin II‐induced cardiac fibrosis by targeting Apelin‐13
Cardiac fibrosis is a major cause of heart failure. MicroRNAs (miRs) are important epigenetic regulators of cardiac function and cardiovascular diseases, including cardiac fibrosis. This study aimed
Metformin attenuates gefitinib-induced exacerbation of pulmonary fibrosis by inhibition of TGF-β signaling pathway
TLDR
It is shown that metformin attenuates gefitinib-induced exacerbation of TGF-β or bleomycin-induced pulmonary fibrosis, which indicates met formin may be combined with EGFR-TKI to treat NSCLC patients.
Herbal supplement attenuation of cardiac fibrosis in rats with CCl₄-induced liver cirrhosis.
TLDR
The results indicated that the OGE and silymarin may be a potential traditional herb for the protection of cardiac tissues from the CCl4 induced cirrhosis associated cardiac fibrosis through modulating the TGF-β signaling pathway.
Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling
TLDR
The results suggest that CTGF is of minimal importance and is an unlikely therapeutic vantage point for the heart, although CTGF has been proposed to function as a critical TGF-β effector in underlying tissue remodeling and fibrosis throughout the body.
miR-203 inhibits arecoline-induced epithelial-mesenchymal transition by regulating secreted frizzled-related protein 4 and transmembrane-4 L six family member 1 in oral submucous fibrosis.
TLDR
Investigation of the role of microRNAs (miRNAs) in arecoline-induced EMT in HaCaT cells found that miR-203 was significantly downregulated in OSF tissues compared to that in normal buccal mucosa tissues, and that mi R-203 negatively regulated secreted frizzled-related protein 4 (SFRP4) and positively regulated transmembrane-4 L six family member 1 (TM4SF1).
Activation of TGF-β1-CD147 positive feedback loop in hepatic stellate cells promotes liver fibrosis
TLDR
Findings indicate that TGF-β1-CD147 loop plays a key role in regulating the HSC activation and combination of T GF-β receptor inhibitor and anti- CD147 antibody might be promised to reverse fibrogenesis.
Serotonin drives the activation of pulmonary artery adventitial fibroblasts and TGF-β1/Smad3-mediated fibrotic responses through 5-HT2A receptors
TLDR
It is demonstrated that 5- HT can directly activate PAFs through 5-HT2A receptor and promote fibroblasts phenotypic alterations and adventitia fibrosis depending on the signaling of the TGF-β1/Smad3 pathway.
Matrix Gla Protein expression pattern in the early avian embryo.
TLDR
Data suggest that MGP expression could be associated with cell migration and differentiation and to the onset of angiogenesis in the developing chick embryo, which has biomedical relevance by pointing to the potential use of chick embryo explants to study molecules involved in artery calcification.
...
...