Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)

  title={Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)},
  author={{\AA}. Hjalmarson and S. Goldstein and B. Fagerberg and H. Wedel and F. Waagstein and J. Kjekshus and J. Wikstrand and G. Westergren and M. Thimell and D. E. Allaf and J. V{\'i}tovec and J. Aldershvile and M. Halinen and R. Dietz and K. Neuhaus and A. J{\'a}nosi and G. Thorgeirsson and P. Dunselman and L. Gullestad and J. Kuch and J. Herlitz and P. Rickenbacher and S. Ball and S. Gottlieb and P. Deedwania and G. Vandenhoven and I. Nov{\'a}kov{\'a} and S. Danker and M. Lundstr{\"o}m and W. Meyer-Sabellek and I. Balla. and M. Sveinsdottir and B. Dorhout and A. Hildebrandt and I. Szczurko and C. Larsson and E. Bucher and E. Scott and D. Dwyer and D. Julian and D. Demets and K. Chatterjee and J. Feyzi and S. Lehto and P. K{\'a}rp{\'a}ti and W. Motz and O. Samuelsson and J. W. Viersma and B. Andersson and C. Berthe and J. M. Boutefeu and G. Boxho and P. Decroly and J. P. Derbaudrenghien and J. Pirlet and P. Henry and G. Heyndrickx and L. Missault and M. Nannan and P. Timmermans and J. L. Vachi{\'e}ry and W. V. Mieghem and J. L. Vandenbossche and K. Dvoř{\'a}k and M. Herold and J. Hradec and A. Kana and P. Petr and J. Rybka and J. Smid and P. Sv{\'i}til and J. Toman and E. Agner and O. Amtorp and K. Egstrup and P. Eliasen and C. G{\o}tzsche and P. Hildebrandt and A. Johannesen and P. Kaiser-Nielsen and H. Nielsen and P. E. Nielsen and F. Pedersen and J. R. Nielsen and K. Skagen and T. Honkanen and E. Hussi and J. Juvonen and H. J{\"a}{\"a}skel{\"a}inen and J. Rinne and T. Salonen and D. Andresen and H. Berwing and Bethge and Beythien and Bischoff. and Bundschu and Daniel and Darius and Delius and Drude and Dingerkus and Dueck and Eichler and Fach and A. F{\"o}rster and Girth and Goss and Hahn and Hambrecht and G. Hauf and Heinemann and Hepp and Janka and Klocke and Konz and B. Krosse and K{\"u}hlkamp and Lewek and B. L{\"u}deritz and Loebe and Maier and Melchior and Mueller and Maeurer and Nast and Neuhaus and Obst and Odemar and K. Olshausen and Pomykaj and K. J. Schmailzl and Schrader and Schroeder and P. Schwimmbeck and M. Sigmund and Simon. and Strasser and Thilo and V{\"o}hringer and H. V{\"o}ller and Weibrodt and Wirtz and I. Czuriga and M. Hetey and A. Katona and M. Lengyel and A. Ny{\'a}r{\'a}di and A. Rednik and K. S{\'a}ndori and P. Szab{\'o} and J. Tarj{\'a}n and J. Tenczer and S. T{\'i}m{\'a}r and P. V{\'a}lyi and G. Veress and K. Z{\'a}molyi and B. {\"O}ze and P. Bernink and A. C. Bredero and R. W. Breedveld and P. Breuls and J. Bucx and J. Cornel and P. A. R. Milliano and B. Hamer and N. Holwerda and J. Hoogsteen and J. C. Hoorntje and J. Kragten and A. H. Liem and G. Linssen and H. R. Michels and A. R. Misier and H. Schaafsma and P. Sijbring and R. J. T. Taverne and L. Kempen and R. V. Stralen and P. J. V. Veldhuisen and M. Veerhoek and C. Werter and J. Wesdorp and A. Willems and A. Withagen and P. Zwart and R. Bj{\o}rnerheim and M. Dahle and K. Dickstein and G. Fr{\o}land and T. Gundersen and K. Hofsoy and T. Hole and T. Johansen and J. Mannsverk and P. Nesje and T. M. Omland and C. Sj{\"o}din and P. Smith and H. A. Tjonndal and O. Vikesdal and K. Waage and Adamus and K. Jaworska and P. Kołodziej and Z. Kornacewicz-Jach and M. Krzeminska-Pakula and J. Piotrowski and W. Piwowarska and A. Stogowski and J. Wodniecki and K. Wrabec and P. Ahlstr{\"o}m and S. Ekdahl and L. O. Hemmingson and L. Holmberg and B. Lernfelt and H. Widgren and K. {\AA}ngman and P. Erne and P. Mohacsi and R. Polikar and H. Schl{\"a}pfer and P. Batin and K. Berkin and T. Callaghan and J. Forfar and M. P. Frenneaux and R. Greenbaum and M. Maltz and D. Murdoch and G. Reynolds and J. Stephens and A. Struthers and J. Swan and G. Tildesley and A. Abbasi and P. Alagona and J. Alderman and M. Alipour and J. Anderson and Z. Ansari and M. Ashraf and B. T. Beanblossom and S. Bennett and D. Benvenuti and M. Berk and R. Bhalla and S. Bilazarian and K. Browne and C. MBuchter and R. Carlson and C. J. Carlson and K. Danisa and I. Dauber and M. Dewood and G. Dennish and D. M. Denny and R. Dibianco and P. Diller and M. Dunlap and K. Dowd and A. Edmiston and M. E. Shahawy and U. Elkayam and J. Farnham and P. Fenster and S. Friedman and T. Heywood and J. Galichia and M. Geller and J. Ghali and M. Gheorghiade and T. Giles and R. Gillespe and G. Goldberg and M. C. Goldberg and D. Goldscher and G. P. Gooden and M. Goodman and L. Goodman and J. Gorwit and A. Gradman and D. Grech and T. Hack and J. Hall and M. Hattenhauer and M. Higginbotham and S. Hutchins and M. Imburgia and B. Iteld and B. Jackson and S. Jafri and W. Jauch and S. Jennison and B. Kahn and W. Kao and K. Kaplan and R. Karlsberg and H. Kennedy and J. J. Kennedy and L. Kirkegaard and D. Kraus and K. LaBresh and L. Lalonde and M. Lesser and R. Levites and M. Levy and R. Lewis and I. Loh and H. Madyoon and F. Maislos and D. Mann and G. L. Maurice and A. Nisar and W. Old and J. Pappas and K. Phadke and S. Promisloff and A. Rashkow and B. Reeves and J. Ros{\'e}n and M. Rotman and T. Saleem and S. Savran and R. Shah and Y. Shalev and J. G. Shanes and M. O'Shaughnessy and B. Silverman and R. Steingart and L. Swenson and K. Syed and U. Thadani and R. Thorsen and M. Tonkon and R. Touchon and G. Uhl and K. Vaska and S. Wagner and C. Weaver and R. Weiss and W. Wickemeyer and H. Willens and J. R. Wilson and R. Wright and L. Yellen},
  journal={The Lancet},
  • Å. Hjalmarson, S. Goldstein, +348 authors L. Yellen
  • Published 1999
  • Medicine
  • The Lancet
  • BACKGROUND: Metoprolol can improve haemodynamics in chronic heart failure, but survival benefit has not been proven. We investigated whether metoprolol controlled release/extended release (CR/XL) once daily, in addition to standard therapy, would lower mortality in patients with decreased ejection fraction and symptoms of heart failure. METHODS: We enrolled 3991 patients with chronic heart failure in New York Heart Association (NYHA) functional class II-IV and with ejection fraction of 0.40 or… CONTINUE READING
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    Metoprolol controlled release/extended release in patients with severe heart failure: analysis of the experience in the MERIT-HF study.
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