Effect of methylmalonate onin vitro lactate release and carbon dioxide production by brain of suckling rats


Methylmalonate (MMA) accumulates in the tissues of patients with methylmalonic acidaemia, who present severe neurological signs soon after birth and later mental retardation. Attempting to understand the pathophysiology of the disorder, we investigated the effects of MMA on brain glucose uptake, lactate release and CO2 production. Glucose uptake and lactate… (More)
DOI: 10.1007/BF01800350


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