Effect of methylene blue and related redox dyes on monoamine oxidase activity; rat pineal content of N-acetylserotonin, melatonin, and related indoles; and righting reflex in melatonin-primed frogs.

@article{Oxenkrug2007EffectOM,
  title={Effect of methylene blue and related redox dyes on monoamine oxidase activity; rat pineal content of N-acetylserotonin, melatonin, and related indoles; and righting reflex in melatonin-primed frogs.},
  author={Gregory Oxenkrug and Sergey O. Sablin and Pura J. Requintina},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1122},
  pages={
          245-52
        }
}
  • Gregory Oxenkrug, Sergey O. Sablin, Pura J. Requintina
  • Published in
    Annals of the New York…
    2007
  • Chemistry, Medicine
  • The ability of methylene blue (MB) to inhibit the nitric oxide-induced stimulation of N-methyl-D-aspartate receptors has been suggested as a possible mechanism of MB's clinical antidepressant action. This study evaluated the alternative/additional mechanisms of the antidepressant effect of MB on biochemical and behavior levels. Selective inhibition of monoamine oxidase type A (MAO-A) is widely accepted as a major mechanism of the clinical antidepressant effect. MB and the related redox dyes… CONTINUE READING

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