Effect of methyl substitution on protein tertiary structure.

  title={Effect of methyl substitution on protein tertiary structure.},
  author={Woon Ki Paik and Sunkyu Kim},
  journal={Journal of theoretical biology},
  volume={155 3},
Biological effects caused by the post-translational methylation of certain side chains in proteins has been thought to be due solely to changes in charge, steric relations or hydrophobicity at the site of the methyl group. However, there is increasing evidence that the presence of CH3 can also induce a "global" effect on the protein molecule. Some of the… CONTINUE READING