Effect of methyl-beta-cyclodextrin on the acrosomal responsiveness of human sperm.

@article{Cross1999EffectOM,
  title={Effect of methyl-beta-cyclodextrin on the acrosomal responsiveness of human sperm.},
  author={Nicholas L. Cross},
  journal={Molecular reproduction and development},
  year={1999},
  volume={53 1},
  pages={92-8}
}
Human sperm incubated in vitro gradually become capable of acrosome-reacting in response to the agonist, progesterone (P4). Loss of unesterified cholesterol is an obligatory step in the development of acrosomal responsiveness. These experiments tested the ability of methyl-beta-cyclodextrin (MbetaCD) to accelerate sperm cholesterol loss and the development… CONTINUE READING