Effect of methotrexate on homocysteine and other sulfur compounds in tissues of rats fed a normal or a defined, choline-deficient diet

@article{Svardal2004EffectOM,
  title={Effect of methotrexate on homocysteine and other sulfur compounds in tissues of rats fed a normal or a defined, choline-deficient diet},
  author={Asbj{\o}rn Martin Svardal and Per Magne Ueland and Rolf Kristian Berge and Asle A Aarsland and Niels Aarsaether and Per Eystein L{\o}nning and Helga Refsum},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={21},
  pages={313-318}
}
SummaryMethotrexate (MTX) affects homocysteine (Hcy) metabolism in both cultured cells and patients, and this may be explained by a lack of the 5-methyltetrahy-drofolate required for salvage of Hcy to methionine. We here report the effect of MTX on Hcy in serum and Hcy, S-adenosylhomocysteine (AdoHcy), S-adenosylmethionine (AdoMet) and reduced glutathione (GSH) in tissues of rats fed either a normal or a defined, choline-deficient (CD) diet. The CD diet alone did not affect the amounts of Hcy… Expand
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