Effect of methotrexate and its photodegradation products on the temperature induced denaturation of human serum albumin.

@article{Preisz2020EffectOM,
  title={Effect of methotrexate and its photodegradation products on the temperature induced denaturation of human serum albumin.},
  author={Zsolt Preisz and S{\'a}ndor Kuns{\'a}gi-M{\'a}t{\'e}},
  journal={Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy},
  year={2020},
  volume={245},
  pages={
          118905
        }
}
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Profiling the interaction of a novel toxic pyruvate dehydrogenase kinase inhibitor with human serum albumin.

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TLDR
Fluorescence spectroscopy and molecular modeling approaches were employed to investigate the binding of methotrexate to human serum albumin (HSA) under physiological conditions and revealed that the binding reaction is spontaneous, and that hydrogen bonds and van der Waals interactions play a major role in the reaction.
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TLDR
Competition for HSA binding between MTX and adriamycin, bleomycin and cyclophosphamide, drugs often used in association with MTX in cancer chemotherapy, was demonstrated.
Fluorescence analysis of competition of phenylbutazone and methotrexate in binding to serum albumin in combination treatment in rheumatology
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AbstractThe thermal denaturation process of bovine and human both fatty acid containing and fatty acid free albumins in aqueous solution was studied by use of differential scanning calorimetry. Human…
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TLDR
A tabulation of high-affinity binding sites for both endogenous and exogenous compounds has been made; it could be useful for the above-mentioned purpose, but it could also be of value when trying to predict potential drug interactions at the protein-binding level.
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TLDR
In a preliminary in vivo experiment, rapid destruction of neovascularisation was observed in the MTX-impregnated conjunctive of the rabbit eye exposed to uncoherent UV and visible light.
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