Effect of methotrexate and its photodegradation products on the temperature induced denaturation of human serum albumin.

@article{Preisz2020EffectOM,
  title={Effect of methotrexate and its photodegradation products on the temperature induced denaturation of human serum albumin.},
  author={Zsolt Preisz and S{\'a}ndor Kuns{\'a}gi-M{\'a}t{\'e}},
  journal={Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy},
  year={2020},
  volume={245},
  pages={
          118905
        }
}
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References

SHOWING 1-10 OF 22 REFERENCES
Insights into the interaction of methotrexate and human serum albumin: A spectroscopic and molecular modeling approach.
TLDR
Fluorescence spectroscopy and molecular modeling approaches were employed to investigate the binding of methotrexate to human serum albumin (HSA) under physiological conditions and revealed that the binding reaction is spontaneous, and that hydrogen bonds and van der Waals interactions play a major role in the reaction.
Modification of human serum albumin binding of methotrexate by folinic acid and certain drugs used in cancer chemotherapy
TLDR
Competition for HSA binding between MTX and adriamycin, bleomycin and cyclophosphamide, drugs often used in association with MTX in cancer chemotherapy, was demonstrated.
Comparative DSC study of human and bovine serum albumin
AbstractThe thermal denaturation process of bovine and human both fatty acid containing and fatty acid free albumins in aqueous solution was studied by use of differential scanning calorimetry. Human
Practical aspects of the ligand-binding and enzymatic properties of human serum albumin.
TLDR
A tabulation of high-affinity binding sites for both endogenous and exogenous compounds has been made; it could be useful for the above-mentioned purpose, but it could also be of value when trying to predict potential drug interactions at the protein-binding level.
Methotrexate as a photosensitiser.
TLDR
In a preliminary in vivo experiment, rapid destruction of neovascularisation was observed in the MTX-impregnated conjunctive of the rabbit eye exposed to uncoherent UV and visible light.
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