Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart

@article{Gmez2009EffectOM,
  title={Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart},
  author={J. G{\'o}mez and P. Caro and In{\'e}s S{\'a}nchez and A. Naud{\'i} and M. Jov{\'e} and M. Portero-Ot{\'i}n and M. L{\'o}pez-Torres and R. Pamplona and G. Barja},
  journal={Journal of Bioenergetics and Biomembranes},
  year={2009},
  volume={41},
  pages={309-321}
}
Methionine restriction without energy restriction increases, like caloric restriction, maximum longevity in rodents. Previous studies have shown that methionine restriction strongly decreases mitochondrial reactive oxygen species (ROS) production and oxidative damage to mitochondrial DNA, lowers membrane unsaturation, and decreases five different markers of protein oxidation in rat heart and liver mitochondria. It is unknown whether methionine supplementation in the diet can induce opposite… Expand
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TLDR
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The mitochondrial free radical theory of aging.
  • G. Barja
  • Biology, Medicine
  • Progress in molecular biology and translational science
  • 2014
TLDR
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Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
TLDR
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Does the oxidative stress theory of aging explain longevity differences in birds? I. Mitochondrial ROS production
TLDR
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Mitochondrial ROS and mtDNA fragments inside nuclear DNA as a main effector of ageing: the "cell aging regulation system”
TLDR
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It is suggested that the decrease in mitROS generation and oxidative damage to mtDNA that occurs during dietary restriction is due to restriction of a single aminoacid: methionine, and for the first time that restriction of dietary amino acids different from methionines decreases mitochondrial protein oxidative modification and AIF, and increases SIRT1, in rat liver. Expand
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TLDR
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