Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart
@article{Gmez2009EffectOM, title={Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart}, author={Jos{\'e} Mar{\'i}a G{\'o}mez and Pilar Caro and In{\'e}s S{\'a}nchez and Alba Naud{\'i} and Mariona Jov{\'e} and Manuel Portero-Ot{\'i}n and M{\'o}nica L{\'o}pez-Torres and R. Pamplona and Gustavo Barja}, journal={Journal of Bioenergetics and Biomembranes}, year={2009}, volume={41}, pages={309-321} }
Methionine restriction without energy restriction increases, like caloric restriction, maximum longevity in rodents. Previous studies have shown that methionine restriction strongly decreases mitochondrial reactive oxygen species (ROS) production and oxidative damage to mitochondrial DNA, lowers membrane unsaturation, and decreases five different markers of protein oxidation in rat heart and liver mitochondria. It is unknown whether methionine supplementation in the diet can induce opposite…
61 Citations
Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart
- BiologyJournal of bioenergetics and biomembranes
- 2011
Results indicate that methionine can be the dietary factor responsible for the decrease in mitochondrial ROS generation and oxidative stress, and likely for part of the increase in longevity, that takes place during DR.
Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria
- BiologyBiogerontology
- 2012
Treating old rats with isocaloric short-term MetR lowers mitROS production and free radical leak and oxidative damage to mtDNA, and reverses aging-related increases in protein modification.
Dietary l-methionine restriction decreases oxidative stress in porcine liver mitochondria
- BiologyExperimental Gerontology
- 2015
Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction
- BiologyExperimental Gerontology
- 2013
Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro
- BiologyJournal of bioenergetics and biomembranes
- 2011
The results show that methionine increases ROS production in liver and kidney mitochondria, homocysteine increases it in kidney and decreases it in the other three organs, and SAM and SAH have no effects.
Methionine restriction affects oxidative stress and glutathione-related redox pathways in the rat
- Biology, ChemistryExperimental biology and medicine
- 2013
Findings indicate that oxidative stress is reduced by MR feeding in rats, but this effect cannot be explained by changes in the activity of antioxidant enzymes.
The mitochondrial free radical theory of aging.
- BiologyProgress in molecular biology and translational science
- 2014
Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Biology, MedicineGenes & Nutrition
- 2017
It is indicated that short-term feeding of MSD substantially alters the normal gut physiology and may contribute to the pathogenesis of intestinal inflammatory diseases and/or sensitize the gut to exposure to other stressors.
Does the oxidative stress theory of aging explain longevity differences in birds? I. Mitochondrial ROS production
- BiologyExperimental Gerontology
- 2012
Mitochondrial ROS and mtDNA fragments inside nuclear DNA as a main effector of ageing: the "cell aging regulation system”
- Biology, Medicine
- 2017
The updated mitochondrial free radical theory of aging (MFRTA) is reviewed as part of the cell aging regulatory system (CARS) and focuses on low mitROSp and low sensitivity of membranes to oxidation in long-lived animals.
References
SHOWING 1-10 OF 69 REFERENCES
Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver
- BiologyBiogerontology
- 2008
It is suggested that the decrease in mitROS generation and oxidative damage to mtDNA that occurs during dietary restriction is due to restriction of a single aminoacid: methionine, and for the first time that restriction of dietary amino acids different from methionines decreases mitochondrial protein oxidative modification and AIF, and increases SIRT1, in rat liver.
Effect of Lipid Restriction on Mitochondrial Free Radical Production and Oxidative DNA Damage
- BiologyAnnals of the New York Academy of Sciences
- 2006
The results deny a role for lipids and reinforce the possible role of dietary proteins as being responsible for the decrease in mitochondrial ROS production and DNA damage in caloric restriction.
Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction possible implications for humans.
- BiologyBiochimica et biophysica acta
- 2008
Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins
- BiologyFASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 2006
For the first time, it is found that methionine restriction profoundly decreases mitROS production, decreases oxidative damage to mtDNA, lowers membrane unsaturation, and decreases all five markers of protein oxidation measured in rat heart and liver mitochondria.
Protein Restriction Without Strong Caloric Restriction Decreases Mitochondrial Oxygen Radical Production and Oxidative DNA Damage in Rat Liver
- BiologyJournal of bioenergetics and biomembranes
- 2004
Part of the decrease in aging rate induced by caloric restriction can be due to the decreased intake of proteins acting through decreases in mitochondrial ROS production and oxidative DNA damage, and these tissue oxidative stress-linked parameters can be lowered by restricting only the intake of dietary protein.
Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver
- BiologyBiogerontology
- 2008
40% isocaloric MetR is enough to decrease ROS production and oxidative stress in rat liver, which suggests that the lowered intake of methionine is responsible for the decrease in oxidative stress observed in DR.
Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.
- BiologyBiochimica et biophysica acta
- 2006
Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage
- BiologyJournal of bioenergetics and biomembranes
- 2006
The results of the present study indicate that the lowered ingestion of dietary proteins is responsible for the decrease in mitochondrial ROS production and oxidative damage in mtDNA that occurs during caloric restriction.
Long-term consumption of a methionine-supplemented diet increases iron and lipid peroxide levels in rat liver.
- BiologyThe Journal of nutrition
- 2000
Results indicate that long-term consumption of excess L-methionine by rats may affect primarily iron metabolism rather than the antioxidant defense system and, consequently, induce an accumulation of iron.
Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain.
- BiologyRejuvenation research
- 2007
It is hypothesized that MetR can be responsible, at least in part, for the decrease in endogenous oxidative damage in CR, and beneficial MetR-induced changes likely derived from metabolic reprogramming at the cellular and tissue level can play a key role in the protection against aging-associated neurodegenerative disorders.