Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart

@article{Gmez2009EffectOM,
  title={Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart},
  author={Jos{\'e} Mar{\'i}a G{\'o}mez and Pilar Caro and In{\'e}s S{\'a}nchez and Alba Naud{\'i} and Mariona Jov{\'e} and Manuel Portero-Ot{\'i}n and M{\'o}nica L{\'o}pez-Torres and R. Pamplona and Gustavo Barja},
  journal={Journal of Bioenergetics and Biomembranes},
  year={2009},
  volume={41},
  pages={309-321}
}
Methionine restriction without energy restriction increases, like caloric restriction, maximum longevity in rodents. Previous studies have shown that methionine restriction strongly decreases mitochondrial reactive oxygen species (ROS) production and oxidative damage to mitochondrial DNA, lowers membrane unsaturation, and decreases five different markers of protein oxidation in rat heart and liver mitochondria. It is unknown whether methionine supplementation in the diet can induce opposite… 
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Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart
TLDR
Results indicate that methionine can be the dietary factor responsible for the decrease in mitochondrial ROS generation and oxidative stress, and likely for part of the increase in longevity, that takes place during DR.
Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria
TLDR
Treating old rats with isocaloric short-term MetR lowers mitROS production and free radical leak and oxidative damage to mtDNA, and reverses aging-related increases in protein modification.
Dietary l-methionine restriction decreases oxidative stress in porcine liver mitochondria
Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction
Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro
TLDR
The results show that methionine increases ROS production in liver and kidney mitochondria, homocysteine increases it in kidney and decreases it in the other three organs, and SAM and SAH have no effects.
Methionine restriction affects oxidative stress and glutathione-related redox pathways in the rat
TLDR
Findings indicate that oxidative stress is reduced by MR feeding in rats, but this effect cannot be explained by changes in the activity of antioxidant enzymes.
The mitochondrial free radical theory of aging.
  • G. Barja
  • Biology
    Progress in molecular biology and translational science
  • 2014
Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
TLDR
It is indicated that short-term feeding of MSD substantially alters the normal gut physiology and may contribute to the pathogenesis of intestinal inflammatory diseases and/or sensitize the gut to exposure to other stressors.
Does the oxidative stress theory of aging explain longevity differences in birds? I. Mitochondrial ROS production
Mitochondrial ROS and mtDNA fragments inside nuclear DNA as a main effector of ageing: the "cell aging regulation system”
TLDR
The updated mitochondrial free radical theory of aging (MFRTA) is reviewed as part of the cell aging regulatory system (CARS) and focuses on low mitROSp and low sensitivity of membranes to oxidation in long-lived animals.
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References

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TLDR
It is suggested that the decrease in mitROS generation and oxidative damage to mtDNA that occurs during dietary restriction is due to restriction of a single aminoacid: methionine, and for the first time that restriction of dietary amino acids different from methionines decreases mitochondrial protein oxidative modification and AIF, and increases SIRT1, in rat liver.
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TLDR
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TLDR
For the first time, it is found that methionine restriction profoundly decreases mitROS production, decreases oxidative damage to mtDNA, lowers membrane unsaturation, and decreases all five markers of protein oxidation measured in rat heart and liver mitochondria.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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