Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart

@article{Gmez2009EffectOM,
  title={Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart},
  author={J. G{\'o}mez and P. Caro and In{\'e}s S{\'a}nchez and A. Naud{\'i} and M. Jov{\'e} and M. Portero-Ot{\'i}n and M. L{\'o}pez-Torres and R. Pamplona and G. Barja},
  journal={Journal of Bioenergetics and Biomembranes},
  year={2009},
  volume={41},
  pages={309-321}
}
Methionine restriction without energy restriction increases, like caloric restriction, maximum longevity in rodents. Previous studies have shown that methionine restriction strongly decreases mitochondrial reactive oxygen species (ROS) production and oxidative damage to mitochondrial DNA, lowers membrane unsaturation, and decreases five different markers of protein oxidation in rat heart and liver mitochondria. It is unknown whether methionine supplementation in the diet can induce opposite… Expand
Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart
Dietary l-methionine restriction decreases oxidative stress in porcine liver mitochondria
Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro
The mitochondrial free radical theory of aging.
  • G. Barja
  • Biology, Medicine
  • Progress in molecular biology and translational science
  • 2014
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Effect of Lipid Restriction on Mitochondrial Free Radical Production and Oxidative DNA Damage
Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins
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