Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart

@article{Gmez2009EffectOM,
  title={Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart},
  author={J. G{\'o}mez and P. Caro and In{\'e}s S{\'a}nchez and A. Naud{\'i} and M. Jov{\'e} and M. Portero-Ot{\'i}n and M. L{\'o}pez-Torres and R. Pamplona and G. Barja},
  journal={Journal of Bioenergetics and Biomembranes},
  year={2009},
  volume={41},
  pages={309-321}
}
Methionine restriction without energy restriction increases, like caloric restriction, maximum longevity in rodents. Previous studies have shown that methionine restriction strongly decreases mitochondrial reactive oxygen species (ROS) production and oxidative damage to mitochondrial DNA, lowers membrane unsaturation, and decreases five different markers of protein oxidation in rat heart and liver mitochondria. It is unknown whether methionine supplementation in the diet can induce opposite… Expand
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Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart
TLDR
Results indicate that methionine can be the dietary factor responsible for the decrease in mitochondrial ROS generation and oxidative stress, and likely for part of the increase in longevity, that takes place during DR. Expand
Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria
TLDR
Treating old rats with isocaloric short-term MetR lowers mitROS production and free radical leak and oxidative damage to mtDNA, and reverses aging-related increases in protein modification. Expand
Dietary l-methionine restriction decreases oxidative stress in porcine liver mitochondria
TLDR
It is indicated that dietary MetR decreases mitochondrial ROS generation primarily via inhibiting complex I activity and ROS generation rather than augmenting anti-oxidative capacity, thereby ameliorating oxidative damage to hepatic mitochondrial DNA and proteins. Expand
Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction
TLDR
It is concluded that lowering mtROS generation is a conserved mechanism, shared by long-lived species and dietary, protein, and methionine restricted animals, that decreases damage to macromolecules situated near the complex ImtROS generator, especially mtDNA. Expand
Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro
TLDR
The results show that methionine increases ROS production in liver and kidney mitochondria, homocysteine increases it in kidney and decreases it in the other three organs, and SAM and SAH have no effects. Expand
Methionine restriction affects oxidative stress and glutathione-related redox pathways in the rat
TLDR
Findings indicate that oxidative stress is reduced by MR feeding in rats, but this effect cannot be explained by changes in the activity of antioxidant enzymes. Expand
The mitochondrial free radical theory of aging.
  • G. Barja
  • Biology, Medicine
  • Progress in molecular biology and translational science
  • 2014
TLDR
The information available supports a mitochondrial free radical theory of aging focused on low generation of endogenous damage and low sensitivity of membranes to oxidation in long-lived animals. Expand
Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
TLDR
It is indicated that short-term feeding of MSD substantially alters the normal gut physiology and may contribute to the pathogenesis of intestinal inflammatory diseases and/or sensitize the gut to exposure to other stressors. Expand
Does the oxidative stress theory of aging explain longevity differences in birds? I. Mitochondrial ROS production
TLDR
A comparison of mitochondrial ROS production in two short-living and three long-living bird species (parrots) that exhibit, on average, a 5-fold longevity difference is reported, casting doubt on the robustness of the oxidative stress theory of aging. Expand
Mitochondrial ROS and mtDNA fragments inside nuclear DNA as a main effector of ageing: the "cell aging regulation system”
TLDR
The updated mitochondrial free radical theory of aging (MFRTA) is reviewed as part of the cell aging regulatory system (CARS) and focuses on low mitROSp and low sensitivity of membranes to oxidation in long-lived animals. Expand
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References

SHOWING 1-10 OF 69 REFERENCES
Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver
TLDR
It is suggested that the decrease in mitROS generation and oxidative damage to mtDNA that occurs during dietary restriction is due to restriction of a single aminoacid: methionine, and for the first time that restriction of dietary amino acids different from methionines decreases mitochondrial protein oxidative modification and AIF, and increases SIRT1, in rat liver. Expand
Effect of Lipid Restriction on Mitochondrial Free Radical Production and Oxidative DNA Damage
TLDR
The results deny a role for lipids and reinforce the possible role of dietary proteins as being responsible for the decrease in mitochondrial ROS production and DNA damage in caloric restriction. Expand
Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction possible implications for humans.
TLDR
These studies suggest that the reduced intake of dietary methionine can be responsible for the decrease in mitochondrial ROS generation and the ensuing oxidative damage that occurs during DR, as well as for part of the increase in maximum longevity induced by this dietary manipulation. Expand
Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins
TLDR
For the first time, it is found that methionine restriction profoundly decreases mitROS production, decreases oxidative damage to mtDNA, lowers membrane unsaturation, and decreases all five markers of protein oxidation measured in rat heart and liver mitochondria. Expand
Protein Restriction Without Strong Caloric Restriction Decreases Mitochondrial Oxygen Radical Production and Oxidative DNA Damage in Rat Liver
TLDR
Part of the decrease in aging rate induced by caloric restriction can be due to the decreased intake of proteins acting through decreases in mitochondrial ROS production and oxidative DNA damage, and these tissue oxidative stress-linked parameters can be lowered by restricting only the intake of dietary protein. Expand
Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver
TLDR
40% isocaloric MetR is enough to decrease ROS production and oxidative stress in rat liver, which suggests that the lowered intake of methionine is responsible for the decrease in oxidative stress observed in DR. Expand
Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.
TLDR
Data suggest that lowering of methionine levels is involved in the control of mitochondrial oxidative stress and vertebrate longevity by at least two different mechanisms: decreasing the sensitivity of proteins to oxidative damage, and lowering of the rate of ROS generation at mitochondria. Expand
Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage
TLDR
The results of the present study indicate that the lowered ingestion of dietary proteins is responsible for the decrease in mitochondrial ROS production and oxidative damage in mtDNA that occurs during caloric restriction. Expand
Long-term consumption of a methionine-supplemented diet increases iron and lipid peroxide levels in rat liver.
TLDR
Results indicate that long-term consumption of excess L-methionine by rats may affect primarily iron metabolism rather than the antioxidant defense system and, consequently, induce an accumulation of iron. Expand
Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain.
TLDR
It is hypothesized that MetR can be responsible, at least in part, for the decrease in endogenous oxidative damage in CR, and beneficial MetR-induced changes likely derived from metabolic reprogramming at the cellular and tissue level can play a key role in the protection against aging-associated neurodegenerative disorders. Expand
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