Effect of methadone addiction on glucose metabolism in rats.

  title={Effect of methadone addiction on glucose metabolism in rats.},
  author={David Sadava and David E. Alonso and Hoi Hong and D P Pettit-Barrett},
  journal={General pharmacology},
  volume={28 1},
Female albino rats were exposed to methadone over a 35-day period by addition of the drug in their drinking water. The final dose of the drug was 1.8 mg/kg body weight per day. After this period, the drug was withdrawn from some animals for 30 days (postexposure). Compared to unexposed controls, serum glucose levels rose during exposure and returned to control levels postexposure. Oral glucose tolerance tests showed impairment in 35-day drug-exposed animals compared to controls and postexposure… CONTINUE READING