Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.

@article{Benes2011EffectOM,
  title={Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.},
  author={Jan Benes and Ludmila Kazdov{\'a} and Zdeněk Drahota and Josef Hou{\vs}těk and Dasa Medrikova and J{\'a}n Kopeck{\'y} and Nikola Kov{\'a}řov{\'a} and Marek Vrback{\'y} and David Sedmera and Hynek Strnad and Michal Kol{\'a}ř and Jir{\'i} Petr{\'a}k and Oldřich Benada and Petra {\vS}karoupkov{\'a} and Luděk {\vC}ervenka and Vojtěch Melenovsk{\'y}},
  journal={Clinical science},
  year={2011},
  volume={121 1},
  pages={29-41}
}
Advanced HF (heart failure) is associated with altered substrate metabolism. Whether modification of substrate use improves the course of HF remains unknown. The antihyperglycaemic drug MET (metformin) affects substrate metabolism, and its use might be associated with improved outcome in diabetic HF. The aim of the present study was to examine whether MET would improve cardiac function and survival also in non-diabetic HF. Volume-overload HF was induced in male Wistar rats by creating ACF… CONTINUE READING