Effect of metformin and pioglitazone on β-catenin and biochemical markers in sitagliptin-induced pancreatitis in diabetic rats

@article{Murad2015EffectOM,
  title={Effect of metformin and pioglitazone on $\beta$-catenin and biochemical markers in sitagliptin-induced pancreatitis in diabetic rats},
  author={Hussam A. S. Murad and Hamid A Saleh and Gamal S. Abdulaziz and May A. Abdulsattar and Soad shaker Ali},
  journal={International Journal of Diabetes in Developing Countries},
  year={2015},
  volume={35},
  pages={332-339}
}
  • H. Murad, H. Saleh, +2 authors S. Ali
  • Published 2015
  • Medicine
  • International Journal of Diabetes in Developing Countries
This study was designed to investigate effect of metformin or pioglitazone on β-catenin and biochemical indicators in sitagliptin-induced pancreatitis. Type 2 diabetes mellitus was induced by high-fat diet/low-dose streptozotocin. Six groups (n = 8) were used: diabetic control group and five treated groups given, for 6 weeks by oral gavage, metformin (100 mg/kg/day), pioglitazone (20 mg/kg/day), sitagliptin (30 mg/kg/day), metformin + sitagliptin (MS), and pioglitazone + sitagliptin (PS). Body… Expand
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