Effect of metal salts on UDPglucuronosyltransferase activity of various aglycones in rat liver microsomesin vitro

@article{Aitio1980EffectOM,
  title={Effect of metal salts on UDPglucuronosyltransferase activity of various aglycones in rat liver microsomesin vitro},
  author={Antero Aitio and Markku Ahotupa and M. G. Parkki},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={1980},
  volume={5},
  pages={35-40}
}
SummaryThe effects of aluminium, manganese, ferrous and ferric iron, cobalt, nickel, copper, zinc, cadmium, barium, mercury and lead ions on the rat hepatic UDPglucuronosyltransferase activity with regard to 4-methylumbelliferone, 4-nitrophenol, bilirubin, and 2-aminophenol were investigatedin vitro. Conjugation of bilirubin was found to be activated by manganese, cobalt, nickel, cadmium, mercury and lead ions in native microsomes, but not in digitonin-treated microsomes. Aluminium, ferrous… CONTINUE READING
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