Effect of metal ions on the rearrangement of dopachrome.

  title={Effect of metal ions on the rearrangement of dopachrome.},
  author={Anna Palumbo and Marco d'Ischia and Giovanna Misuraca and Giuseppe Prota},
  journal={Biochimica et biophysica acta},
  volume={925 2},
In vitro experiments are reported showing that a number of transition metal ions exert a profound influence on both the kinetics and chemical course of the rearrangement of dopachrome, a key step in the biosynthesis of melanins. HPLC analysis shows that Cu2+, Ni2+ and Co2+ are particularly effective in inducing the non-decarboxylative rearrangement of dopachrome at physiological pH values, leading mainly to 5,6-dihydroxyindole-2-carboxylic acid, whereas in the absence of metal ions the reaction… CONTINUE READING


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