Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex.

@article{Marenco2006EffectOM,
  title={Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex.},
  author={Stefano Marenco and Sonya Ulrike Steele and Michael F. Egan and Terry E. Goldberg and Richard E Straub and Anjail Z. Sharrief and Daniel R. Weinberger},
  journal={The American journal of psychiatry},
  year={2006},
  volume={163 4},
  pages={740-2}
}
OBJECTIVE This study was carried out to confirm prior evidence of an effect of a single nucleotide polymorphism (SNP) in the metabotropic glutamate receptor 3 (GRM3) gene (a putative risk factor for schizophrenia) on measures of N-acetylaspartate in healthy comparison subjects. METHOD Fifty-four carefully screened healthy volunteers genotyped at SNP rs6465084 underwent magnetic resonance spectroscopic imaging (MRSI) at 3 T and selected neuropsychological testing. RESULTS The A/A genotype… CONTINUE READING

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