Effect of metabolic inhibitors on uptake of non-transferrin-bound iron by reticulocytes.

@article{Qian1991EffectOM,
  title={Effect of metabolic inhibitors on uptake of non-transferrin-bound iron by reticulocytes.},
  author={Zhong-Ming Qian and Evan H. Morgan},
  journal={Biochimica et biophysica acta},
  year={1991},
  volume={1073 3},
  pages={456-62}
}
The relationship between transferrin-free iron uptake and cellular metabolism was investigated using rabbit reticulocytes in which energy metabolism was altered by incubation with metabolic inhibitors (antimycin A, 2,4-dinitrophenol, NaCN, NaN3 and rotenone) or substrates. Measurements were made of cellular ATP concentration and the rate of uptake of Fe(II) from a sucrose solution buffered at pH 6.5. There was a highly significant correlation between the rate of iron uptake into cytosolic and… CONTINUE READING

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