Effect of metabolic acidosis on the growth hormone/IGF-I endocrine axis in skeletal growth centers.

@article{Green2000EffectOM,
  title={Effect of metabolic acidosis on the growth hormone/IGF-I endocrine axis in skeletal growth centers.},
  author={Jacob Green and Gila Maor},
  journal={Kidney international},
  year={2000},
  volume={57 6},
  pages={2258-67}
}
BACKGROUND Chronic metabolic acidosis (CMA) adversely affects bone metabolism and skeletal growth. Given the cardinal role played by the local growth hormone (GH)/insulin-like growth factor-I (IGF-I) in promoting cell proliferation and differentiation in growth plates, we tested the effect of CMA on the GH/IGF-I axis in a skeletal growth center. METHODS We employed an in vitro organ culture system using the murine mandibular condyle as a model for endochondral active growth center. Condyles… CONTINUE READING

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