Effect of metabolic acidosis on progression of chronic kidney disease.

  • Jeffrey A. Kraut
  • Published 2011 in American journal of physiology. Renal physiology


METABOLIC ACIDOSIS, TRADITIONALLY defined as a reduction in serum HCO3 concentration ([HCO3 ]) often associated with a detectable reduction in blood pH, is a common accompaniment of progressive chronic kidney disease (CKD) (7). The metabolic acidosis even when mild is not without consequences: increased degradation of muscle protein with muscle wasting (1… (More)
DOI: 10.1152/ajprenal.00074.2011


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