Effect of melittin on potassium currents and action potential in ventricular myocytes of guinea pig.

Abstract

AIM To examine the effects of melittin (Mel), the major component of bee venom, on delayed rectifier K+ current (Ik), inward rectifier K+ current (Ikl) and action potential (AP) in guinea pig ventricular myocytes. METHODS Ik, Ikl, and AP were recorded using the whole-cell patch-clamp technique. RESULTS The action potential duration (APD) was shortened… (More)

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