Effect of medroxyprogesterone acetate on thyrotropin secretion in adult and old female rats.

@article{Moreira2000EffectOM,
  title={Effect of medroxyprogesterone acetate on thyrotropin secretion in adult and old female rats.},
  author={Rachel Moraes Moreira and Paulo Paschoal Borges and P C Lisb{\^o}a and Flavio Henrique Curty and E G Moura and Carmen Cabanelas Pazos-Moura},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2000},
  volume={33 9},
  pages={1111-8}
}
Steroid hormones have been implicated in the modulation of TSH secretion; however, there are few and controversial data regarding the effect of progesterone (Pg) on TSH secretion. Medroxyprogesterone acetate (MPA) is a synthetic alpha-hydroxyprogesterone analog that has been extensively employed in therapeutics for its Pg-like actions, but that also has some glucocorticoid and androgen activity. Both hormones have been shown to interfere with TSH secretion. The objective of the present study… CONTINUE READING