Effect of medium pH on the cytotoxicity of hydrophilic statins.

@article{Kobayashi2007EffectOM,
  title={Effect of medium pH on the cytotoxicity of hydrophilic statins.},
  author={Masaki Kobayashi and Toshiki Kagawa and Rumi Takano and Shirou Itagaki and Takeshi Hirano and Ken Iseki},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  year={2007},
  volume={10 3},
  pages={332-9}
}
PURPOSE The aim of this study was to examine the mechanism of pravastatin- and rosuvastatin-induced cytotoxicity and the relationship between pravastatin- and rosuvastatin-induced cytotoxicity and medium pH using human prototypic embryonal rhabdomyosarcoma cell line (RD) and rat myoblast cell line (L6) as a model of in vitro skeletal muscle. METHODS Statin-induced reduction of cell viability and apoptosis was measured by 3-(4,5-dimethylthiazol-2-yl)2,5 -diphenyl tetrazolium bromide (MTT… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 15 references

Relationship between water-octanol partition coefficient and inhibition of proliferation of cultured cell lines among various HMG-CoA reductase inhibitors

  • N. Maeda, H. Yokota, +5 authors Y. Seda
  • (Statins).Prog Med,
  • 2004
1 Excerpt

Relationship between wateroctanol partition coefficient and inhibition of proliferation of cultured cell lines among various HMG - CoA reductase inhibitors ( Statins )

  • N. Maeda, H. Yokota, +5 authors Y. Seda
  • Prog Med
  • 2004

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