Effect of medetomidine on the pharmacokinetics of propofol in dogs.

@article{Hall1994EffectOM,
  title={Effect of medetomidine on the pharmacokinetics of propofol in dogs.},
  author={Les W Hall and E Lagerweij and Andrea Mary Nolan and John William Sear},
  journal={American journal of veterinary research},
  year={1994},
  volume={55 1},
  pages={116-20}
}
Pharmacokinetic variables of propofol were investigated in 6 mixed-breed dogs, and the effect of medetomidine (10 micrograms/kg of body weight) on these kinetics was investigated using a two-way crossover design. On 2 occasions, dogs received either a bolus dose of propofol sufficient to allow endotracheal intubation, followed by an infusion of propofol (0.4 mg/kg/min) for 120 minutes, or medetomidine (10 micrograms/kg, IM), 15 minutes prior to induction of anesthesia as described, followed by… CONTINUE READING