Effect of meclofenamate or ketoconazole on the natriuretic response to increased pressure.

@article{Haas1996EffectOM,
  title={Effect of meclofenamate or ketoconazole on the natriuretic response to increased pressure.},
  author={John A Haas and Franklyn G. Knox},
  journal={The Journal of laboratory and clinical medicine},
  year={1996},
  volume={128 2},
  pages={202-7}
}
Increases in renal interstitial hydrostatic pressure (RIHP) by direct renal interstitial volume expansion (DRIVE) decrease proximal sodium reabsorption and increase urinary fractional sodium excretion (FENa). This natriuretic response is blunted by inhibition of the cyclooxygenase pathway. However, complicating the interpretation of the effects of cyclooxygenase inhibition on sodium excretion are the following: (1) products of the other pathways of arachidonic acid metabolism, such as the… CONTINUE READING