Effect of mechanical ventilation strategy on dissemination of intratracheally instilled Escherichia coli in dogs.

@article{Nahum1997EffectOM,
  title={Effect of mechanical ventilation strategy on dissemination of intratracheally instilled Escherichia coli in dogs.},
  author={Avi Nahum and J P Hoyt and Lawrence Schmitz and Jill Moody and Robert Shapiro and John J. Marini},
  journal={Critical care medicine},
  year={1997},
  volume={25 10},
  pages={1733-43}
}
OBJECTIVE To test the effect of different mechanical ventilation strategies on dissemination of intratracheally instilled Escherichia coli in dogs and to determine the extent and distribution of lung damage. DESIGN Prospective, randomized study. SETTING Experimental animal laboratory. SUBJECTS Eighteen anesthetized and paralyzed dogs. INTERVENTIONS We studied the effect of three ventilatory strategies based on two variables: transpulmonary pressure and positive end-expiratory pressure… CONTINUE READING

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