Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial.

@article{Ranieri1999EffectOM,
  title={Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial.},
  author={V. Marco Ranieri and Peter M. Suter and Cosimo Tortorella and Roberta De Tullio and Jean-Michel Dayer and Adriana Brienza and Francisco Bruno and Arthur S Slutsky},
  journal={JAMA},
  year={1999},
  volume={282 1},
  pages={54-61}
}
CONTEXT Studies have shown that an inflammatory response may be elicited by mechanical ventilation used for recruitment or derecruitment of collapsed lung units or to overdistend alveolar regions, and that a lung-protective strategy may reduce this response. OBJECTIVE To test the hypothesis that mechanical ventilation induces a pulmonary and systemic cytokine response that can be minimized by limiting recruitment or derecruitment and overdistention. DESIGN AND SETTING Randomized controlled… CONTINUE READING
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